Spreading depolarization can cause secondary injury after TBI
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چکیده
منابع مشابه
Mechanisms of spreading depression and hypoxic spreading depression-like depolarization.
Spreading depression (SD) and the related hypoxic SD-like depolarization (HSD) are characterized by rapid and nearly complete depolarization of a sizable population of brain cells with massive redistribution of ions between intracellular and extracellular compartments, that evolves as a regenerative, "all-or-none" type process, and propagates slowly as a wave in brain tissue. This article revie...
متن کاملSpreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortex
Spreading depolarization of cells in cerebral grey matter is characterized by massive ion translocation, neuronal swelling and large changes in direct current-coupled voltage recording. The near-complete sustained depolarization above the inactivation threshold for action potential generating channels initiates spreading depression of brain activity. In contrast, epileptic seizures show modest ...
متن کاملTITLE : Spreading depressions as secondary insults after traumatic injury to the human brain PRINCIPAL
s and Conference Presentations: Hartings JA, Okonkwo DO, Bullock MR, Shutter LA, Mathern B, Strong AJ. Spreading depolarizations and outcome after traumatic brain injury: a prospective observational study. Military Health System Research Symposium (8 Aug 2012; Ft. Lauderdale, FL). Hartings JA, Bullock MR, Zacko C, Vidgeon S, Ridder T, Stanger R, Fabricius M, Mathern B, Tolias C, Pahl C, Strong ...
متن کاملCan mild head injury cause ischaemic stroke?
Five cases of ischaemic stroke preceded by minor head trauma in children are described. All patients had striatocapsular infarction. Three had no cerebrovascular abnormality; two had turbulent flow in the proximal middle cerebral artery. None of the patients had evidence of arterial dissection or any other risk factors for stroke. All made an excellent neurological recovery. Possible mechanisms...
متن کاملIschemia-induced spreading depolarization in the retina.
Cortical spreading depolarization is a metabolically costly phenomenon that affects the brain in both health and disease. Following severe stroke, subarachnoid hemorrhage, or traumatic brain injury, cortical spreading depolarization exacerbates tissue damage and enlarges infarct volumes. It is not known, however, whether spreading depolarization also occurs in the retina in vivo. We report now ...
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ژورنال
عنوان ژورنال: Nature Reviews Neurology
سال: 2014
ISSN: 1759-4758,1759-4766
DOI: 10.1038/nrneurol.2014.169